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The United States had seen decades of continually declining mortality rates, as advances in health care and safety have allowed us to live longer. This century, however, mortality rates among certain demographic and socioeconomic groups have increased. A recent study attributes this uptick to what the authors call “deaths of despair,” which are drug and alcohol overdoses, liver disease associated with chronic alcohol use, and suicide. To save lives, we must replace the consequences of despair with the promises of hope – health, knowledge, prevention, and effective treatment.